Key recent publications
Chandrabalan A., McPhillie M.J.,Morice A., Sadofsky L., Boa A. N-Cinnamoylanthranilates as human TRPA1 Modulators: Structure-Activity Relationships and Channel Binding Sites European Journal of Medicinal Chemistry, 2019, DOI: 10.1016/j.ejmech.2019.02.074
El Bissati K., Redel H., Ting L-M., Lykins J., McPhillie M.J., Upadhya R., Woster P.M., Yarlett N., Kim K., Weiss L.M. Novel Synthetic Polyamines have potent antimalarial activities in vitroand in vivoby decreasing intracellular spermidine and spermine concentrations Frontiers in Cellular and Infection Microbiology, 2019, 409301.
Lykins J., Filippova E.V., Halavaty A.S., Minasov G., Zhou Y., Dubrovska I., Flores K., Shuvalova L., Ruan J., El Bissati K., Dovgin S., Roberts C.W., Woods S., Moulton J.D., Moulton H., McPhillie M.J., Muench S.P., Fishwick C.W.G., Sabini E., McLeod R., Anderson W.F., Ngô N. CSGID identifies phenotypes and solves structures for five enzymes in toxoplasma gondii, Frontiers in Cellular and Infection Microbiology, 2018, 8, 352.
Rawson S., Bisson C., Hurdiss D., Fazal A., McPhillie M., Sedelnikova S., Baker P., Rice D.W., Muench S.P. Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM, PNAS, 2018, DOI:10.1073/pnas.1708839115.
Victoria Easton, Martin McPhillie, John Barr, Thomas Edwards, Richard Foster, Colin Fishwick, and Mark Harris Identification of a small molecule inhibitor of Ebolavirus genome replication and transcription using in silico screening. Antiviral Res., 2018, 156, 46 – 54
Samuel Oldknow, Mark A. Blitz, Colin W. G. Fishwick, Diego Rota Martir, Victoria E. Pritchard, Eli Zysman-Colman and Michaele J. Hardie Photo-induced structure-switching isomerisation of M3L2 Ir(III) coordination cages with host-ligands with multiple azoaromatic groups. Chem. Sci., 2018, ASAP DOI: 10.1039/c8sc03499k.
Kangsa Amporndanai, Rachel Johnson, Paul O'Neil, Colin WG Fishwick, Harry Jamson Shaun Rawson, Stephen P Muench, S Samar Hasnain, Svetlana V Antonyuk X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complex for structure-based drug discovery. IUCrJ., 2018, in press.
Emma L. Millington, H. Ali Dondas, Colin W.G. Fishwick, Colin Kilner and Ron Grigg Catalytic Bimetallic [Pd(0)/Ag(I)] Heck-1,3-Dipolar Cycloaddition Cascade Reactions Accessing Spiro-oxindoles. In situ Generation of Azomethine Ylides and Dipolarophiles. Tetrahedron, 2018, in press.
Ricky Cain, Jürgen Brem, David Zollman, Michael A. McDonough, Rachel Johnson, James Spencer, Anne Makena, Martine I. Abboud, Samuel Cahill, Sook Y. Lee, Peter J. McHugh, Christopher J. Schofield, and Colin W. G. Fishwick In silico fragment based design identifies potent β-lactamase inhibitors. J. Med. Chem., 2018, 61 (3), 1255–1260.
James I. Robinson, Darren C. Tomlinson, Euan W. Baxter, Robin L. Owen, Stephanie J. Win, Joanne E. Nettleship, Christian Tiede, Richard J. Foster, Mark P. Waterhouse, Sarah A. Harris, Raymond J. Owens, Colin W.G. Fishwick, Michael J. McPherson, Ann W. Morgan Adhirons inhibit immune complex binding to Fcgreceptor IIIa with high specificity and reveal novel allosteric hot spots for therapeutic targeting. PNAS, 2018, 115(1): E72 - E81.
Lewis D. Turner, Abbey J. Summers, Laura O. Johnson, Margaret A. Knowles, and Colin W. G. Fishwick Identification of an Indazole-Based Pharmacophore for the Inhibition of FGFR Kinases Using Fragment-Led de Novo Design. ACS Med. Chem. Lett., 2017, 8 (12), 1264 – 1268
Johnson R., Rawson S., McPhillie M., Fishwick C., Muench S. The Growing Role of Electron Microscopy in Anti-parasitic Drug Discovery. Current Medicinal Chemistry, 2018, 25, 1 – 12
Karina Calvopiña, Philip Hinchliffe, Jürgen Brem, Samar Johnson, Kate J. Heesom, Ricky Cain, Christopher T. Lohans, Colin W. G. Fishwick, Christopher J. Schofield, James Spencer, and Matthew B. Avison Structural/mechanistic insights into the efficacy of non-classical beta-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates. Molecular Microbiology, 2017, 106(3), 492 – 504
Batson S., Chiara C., Majce V., Lloyd A.J., Gobec S., Dean Rea, Vilmos Fulop, Katie J. Simmons, Colin W.G. Fishwick, Luiz Pedro S. de Carvalho, & David I Roper Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Nature Communications, 2017, 8 (1), 2041 – 1723
Gordon J.A., Fishwick C.W., McPhillie M.J. New Opportunities in the Structure-based Design of Anti-Protozoan Agents. Current Topics in Medicinal Chemistry, 2017, 17, 1 – 13.
Rawson S., McPhillie M.J., Johnson R.M., Fishwick C.W.G., Muench S.P. The potential use of single-particle electron microscopy as a tool for structure-based inhibitor design. Acta Crystallographica Section D: Structural Biology, 2017, 73(6) 534 – 540
Dilly S.J., Clark A.J., Marsh A., Mitchell D.A., Cain R., Fishwick C.W., Taylor P.C. A chemical genomics approach to drug reprofiling in oncology: Antipsychotic drug risperidone as a potential adenocarcinoma treatment. Cancer Lett. 2017, 393, 16 – 21
Glenn A. McConkey, Paul T. P. Bedingfield, David R. Burrell, Nicholas C. Chambers, Fraser Cunningham, Timothy J. Prior, Colin W.G. Fishwick, Andrew N. Boa. Interconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modesInterconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modes. Bioorg. Med. Chem. Lett., 2017, 27, 3878 – 3882.
Samuel T. Cahill, Ricky Cain, David Y. Wang, Christopher T. Lohans, David W. Wareham, Henry P. Oswin, Jabril Mohammed, James Spencer, Colin W. G. Fishwick, Michael A. McDonough, Jürgen Brem & Christopher J. Schofield. Cyclic Boronates Inhibit All Classes of beta-Lactamase. Antimicrobial Agents and Chemotherapy, 2017, DOI: 10.1128/AAC.02260-16.
Flora L. Thorp-Greenwood, Alexander D. Brennan, Samuel Oldknow, James J. Henkelis, Katie J. Simmons, Colin W. G. Fishwick and Michaele J. Hardie. Tris-N-alkylpyridinium-functionalised cyclotriguaiacylene hosts as axles in branched [4]pseudorotaxane formation. Supramol. Chem., 2017, 29, 430 – 440.
Kaye K., Bryant D.E., Marriott K.E.R., Ohara S., Fishwick C.W.G., Kee T.P. Selective Phosphonylation of 5′-Adenosine Monophosphate (5′-AMP) via Pyrophosphite [PPi(III)]. Origins of Life and Evolution of Biospheres, 2016, 46(4), 425 – 434.
Emily A. Caseley, Stephen P. Muench, Stephen A. Baldwin, Colin W. Fishwick and Lin-Hua Jiang. Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists. Biochemical Pharmacology, 2016, 116, 130 – 139.
Grigg R., Elboray E.E., Akkarasamiyo S., Chuanopparat N., Dondas H.A., Abbas-Temirek H.H., Fishwick C.W.G., Aly M.F., Kongkathip B., Kongkathip N. A Facile Palladium Catalysed 3-Component Cascade Route to Functionalised Isoquinolinones and Isoquinolines. Chem. Commun., 2016, 52, 164 – 166.
Dondas H.A., Hempshall A., Narramore S., Kilner C., Fishwick C.W.G., Grigg R. γ-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3- and 5- component cascades. Tetrahedron, 2016, 72, 1316 – 1329.
Martin McPhillie, Ying Zhou, Kamal El Bissati, Jitender Dubey, Hernan Lorenzi, Michael Capper, Amanda K. Lukens, Mark Hickman, Stephen Muench, Shiv Kumar Verma, Christopher R. Weber, Kelsey Wheeler, James Gordon, Justin Sanders, Hong Moulton, Kai Wang , Taek-Kyun Kim, Yuqing He, Tatiana Santos, Stuart Woods, Patty Lee, David Donkin, Eric Kim, Laura Fraczek, Joseph Lykins, Farida Esaa, Fatima Alibana-Clouser, Sarah Dovgin, Louis Weiss, Gael Brasseur, Dyann Wirth , Michael Kent, Leroy Hood, Brigitte Meunieur, Craig W. Roberts, S. Samar Hasnain, Svetlana V. Antonyuk, Colin Fishwick, and Rima McLeod. New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections. Scientific Reports, 2016, 29179.
Jürgen Brem, Ricky Cain, Samuel Cahill, Michael A. McDonough, Ian J. Clifton, Juan-Carlos Jiménez-Castellanos, Matthew B. Avison, James Spencer, Colin W. G. Fishwick, and Christopher J. Schofield. Structural basis of metallo-β-lactamase, serine-β-lactamase, and penicillin binding protein inhibition by cyclic boronates. Nature Communications, 2016, 7, 121406.